RABID stars Marilyn Chambers as Rose, a woman who is seriously injured in a motorcycle accident. She, and her boyfriend Hart (Frank Moore), who was driving the motorcycle, are taken to the nearby Keloid Clinic, a hospital for plastic surgery. In order to treat Rose, Dr. Keloid (Howard Ryshpan) decides to give her an experimental treatment in which skin grafts are neutralized so that they will adapt to any part of the body. The surgery appears to be a success until Rose awakens and finds that she now has a stinger-like appendage which now emerges from her armpit in order to suck blood from other humans. (I promise, I'm not making this up.) As if that weren't bad enough, anyone that Rose attacks soon exhibits violent, out-of-control behavior, and then dies. Consumed by her insatiable need to feed, Rose attacks more and more people, which leads to an epidemic of sadistic behavior.